Skullomania’s design was inspired by the Japanese superhero Kamen Rider created by the late manga author Shotaro Ishinomori, with extra elements drawn from the Skull Man, a character from a manga Ishinomori wrote in order to work out the concepts for Kamen Rider. Skullomania also draws from real-life luchador La Parka (also known as The Reaper/Death).
In Street Fighter EX, Skullomania’s costume is simply a black body stocking with a skeleton motif printed on it. The Kamen Rider/”Skull Rider” image was enhanced in Street Fighter EX2, where Skullomania’s costume gained a red scarf, gloves, and boots, as well as a belt almost identical to the Typhoon belt worn by Hayato Ichimonji, Kamen Rider #2. Both the belt and the forehead of Skullo’s mask bear a stylized letter “S”.